Platelet activation and thrombosis: Studies in a patient with essential thrombocythemia
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چکیده
منابع مشابه
INFERIOR VENA CAVA THROMBOSIS IN A PATIENT WITH ESSENTIAL THROMBOCYTHEMIA
Essential thrombocythemia is a chronic myeloproliferative disorder characterized by a sustained proliferation of megakaryocytes, which leads to increased numbers of circulating platelets. Hemorrhagic and/or thrombotic episodes are frequent, and thrombosis of both veins and arteries may develop. Vessels in unusual sites may be involved, e.g., the hepatic veins, mesenteric veins, and the dig...
متن کاملinferior vena cava thrombosis in a patient with essential thrombocythemia
essential thrombocythemia is a chronic myeloproliferative disorder characterized by a sustained proliferation of megakaryocytes, which leads to increased numbers of circulating platelets. hemorrhagic and/or thrombotic episodes are frequent, and thrombosis of both veins and arteries may develop. vessels in unusual sites may be involved, e.g., the hepatic veins, mesenteric veins, and the digital ...
متن کاملPlatelet activation and inhibition in polycythemia vera and essential thrombocythemia.
Persistently enhanced platelet activation has been characterized in polycythemia vera (PV) and essential thrombocythemia (ET) and shown to contribute to a higher risk of both arterial and venous thrombotic complications. The incidence of major bleeding complications is also somewhat higher in PV and ET than in the general population. Although its efficacy and safety was assessed in just 1 relat...
متن کاملEnhanced platelet adhesion in essential thrombocythemia after in vitro activation.
OBJECTIVE Essential thrombocythemia (ET) is a chronic myeloproliferative disorder characterized by elevated platelet counts and increased risk of thrombosis. Ex vivo data suggest increased platelet reactivity in agreement with the increased thrombosis risk, while in vitro tests often detect decreased platelet activity. The present study aimed to investigate adhesion of ET-platelets in vitro, wh...
متن کاملIncreased platelet and leukocyte activation as contributing mechanisms for thrombosis in essential thrombocythemia and correlation with the JAK2 mutational status.
BACKGROUND AND OBJECTIVES The mechanisms accounting for the increased risk of thrombosis in patients with essential thrombocythemia (ET) are not well known. The aim of the present study was to ascertain the role of platelet and leukocyte activation in the thrombosis of ET. DESIGN AND METHODS The activation status of platelets and leukocytes was assessed by flow cytometry studies in 49 patient...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1996
ISSN: 0361-8609,1096-8652
DOI: 10.1002/(sici)1096-8652(199601)51:1<79::aid-ajh13>3.0.co;2-6